Impact of online adaptations on clinical trial design
The goal is to develop suitable design for adaptations in clinical studies
Principal Investigator: Sara Pilskog
Team/collaborators: Terje Norberg, Gry S. Haaland, Marianne Brydøy
Background
Numerous studies have investigated the potential of adaptive photon or proton therapy for dose-escalation and/or healthy tissue sparing for curative treatments. The transition to clinical implantation and subsequent clinical evidence of benefit is however extremely scarce. Dedicated systems (Ethos (TM) and MR-Linacs ) for online adaptive radiotherapy i.e. where the treatment plan is adapted while the patient is laying on the treatment table, have led to more patients treated with online ART also outside of clinical studies. How to account for these differences in clinical practice among centres, creates unresolved challenges when designing international and national trials comparing photon with protons. In WP4 we will investigate implementation strategies for adaptation in proton and photon therapy and use these investigations to advise on suitable design for clinical studies.
Goal
Develop suitable design for adaptations in clinical studies.
Impact
The novel strategies developed and compared can expand the use of adaptations and improve treatment by reducing toxicity and/or enable dose-escalation. The results could improve trials comparing photons and protons with adaptation in one or both arms.