Antimikrobielle resistensforhold

Kristiansen, T., Moyo, S.J et al. Antimicrobial resistance in paediatric bloodstream infections in Tanzania: a longitudinal comparison of two cohort studies. BMC Microbiol (2026). https://doi.org/10.1186/s12866-026-05024-5

Bargheet A, Moyo SJ, Löhr IH, Blomberg B, Langeland N, Pettersen VK. Metabolic reprogramming of the infant gut by bifidobacteria-based probiotics drives exclusion of antibiotic-resistant pathobionts. Cell Rep Med. 2026 Apr 20:102752. doi: 10.1016/j.xcrm.2026.102752. Epub ahead of print. PMID: 42013844.

Klingenberg, Claus, ... Bjørn Blomberg, Nina Langeland. Home administration of a multistrain probiotic once per day for 4 weeks to newborn infants in Tanzania (ProRIDE): a double-blind, placebo-controlled randomised trial.The Lancet Global Health, Volume 13, Issue 6, e1082 - e1090

Moyo SJ, Manyahi J, Aboud S, Mørch K, Roberts AP, Blomberg B, Langeland N. Extended-spectrum-β-lactamase-producing Gram-negative bacteria are associated with high mortality in children with bloodstream infections in Dar es Salaam, Tanzania. BMC Infect Dis. 2025 Oct 27;25(1):1416. doi: 10.1186/s12879-025-11629-4. PMID: 41146114; PMCID: PMC12560594.

Renz J,....Blomberg B, Johnston IG. Evolutionary accumulation modeling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance. mBio. 2025 Jun 11;16(6):e0048825. doi: 10.1128/mbio.00488-25. Epub 2025 May 21. PMID: 40396716; PMCID: PMC12153324.

Robins D, ... Blomberg B, Langeland N, Moyo S, Roberts AP. Genome sequence of antibiotic-resistant Klebsiella quasipneumoniae FSFC0558: a novel sequence type (ST8212). Access Microbiol. 2025 Apr 25;7(4):000944.v3. doi: 10.1099/acmi.0.000944.v3. PMID: 40292017; PMCID: PMC12032403.

Goodman RN, Moyo SJ, ...Blomberg B, Langeland N, Roberts AP. Comparative genomics of blood and faecal E. coli and K. pneumoniae isolates from neonates with bloodstream infections in Tanzania. Commun Biol. 2025 Nov 18;8(1):1603. doi: 10.1038/s42003-025-09008-5. PMID: 41254151; PMCID: PMC12627497.

Mapunda L, ...Blomberg B, Manyahi J. Co-existence of two bla_NDM-5 and bla_OXA-181 on distinct plasmids in a carbapenem-resistant Klebsiella pneumoniae from a tertiary hospital, Tanzania. J Glob Antimicrob Resist. 2025 Mar;41:173-180. doi: 10.1016/j.jgar.2024.12.011. Epub 2025 Jan 2. PMID: 39755167.

Onken A, Moyo S, Miraji MK, Bohlin J, Marijani M, Manyahi J, Kibwana KO, Müller F, Jenum PA, Abeid KA, Reimers M, Langeland N, Mørch K, Blomberg B. Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar. PLoS Negl Trop Dis. 2024 Apr 17;18(4):e0012132. doi: 10.1371/journal.pntd.0012132. PMID: 38630840

Manyahi J, Moyo SJ, Langeland N, Blomberg B. Genetic determinants of macrolide and tetracycline resistance in penicillin non-susceptible Streptococcus pneumoniae isolates from people living with HIV in Dar es Salaam, Tanzania.​ Ann Clin Microbiol Antimicrob. 2023 Feb 20;22(1):16. doi: 10.1186/s12941-023-00565-3. PMID: 36803640.​

Kibwana UO, Manyahi J, Sandnes HH, Blomberg B, Mshana SE, Langeland N, Roberts AP, Moyo SJ. Fluoroquinolone resistance among fecal extended spectrum βeta lactamases positive Enterobacterales isolates from children in Dar es Salaam, Tanzania. BMC Infect Dis. 2023 Mar 7;23(1):135. doi: 10.1186/s12879-023-08086-2. PMID: 36882712

Katyali D, Kawau G, Blomberg B, Manyahi J. Antibiotic use at a tertiary hospital in Tanzania: findings from a point prevalence survey. Antimicrob Resist Infect Control. 2023 Oct 10;12(1):112. doi: 10.1186/s13756-023-01317-w. PMID: 37817204; PMCID: PMC10566109.​​

Manyahi J, Moyo SJ, Kibwana U, Goodman RN, Allman E, Hubbard ATM, Blomberg B, Langeland N, Roberts AP. First identification of blaNDM5 producing Escherichia coli from neonates and a HIV infected adult in Tanzania.  J Med Microbiol. 2022 Feb;71(2):001513. doi: 10.1099/jmm.0.001513. PMID: 35225760​​  

Kibwana UO, Manyahi J, Sandnes HH, Blomberg B, Mshana SE, Langeland N, Moyo SJ. Gastrointestinal colonization of extended-spectrum beta-lactamase-producing bacteria among children below five years of age hospitalized with fever in Dar es Salaam, Tanzania. J Glob Antimicrob Resist. 2022 Jun 3;30:107-114. doi: 10.1016/j.jgar.2022.05.023. PMID: 35667646.

Manyahi J, Moyo SJ, Tellevik MG, Langeland N, Blomberg B. High Prevalence of Fecal Carriage of Extended Spectrum β-Lactamase-Producing Enterobacteriaceae Among Newly HIV-Diagnosed Adults in a Community Setting in Tanzania. Microb Drug Resist. 2020 Dec;26(12):1540-1545. doi: 10.1089/mdr.2020.0066.

Manyahi J, Moyo S, Aboud S, Langeland N, Blomberg B. High rate of antimicrobial resistance and multiple mutations in the dihydrofolate reductase gene among Streptococcus pneumoniae isolated from HIV-infected adults in a community setting in Tanzania. J Glob Antimicrob Resist. 2020 Sep;22:749-753. doi:10.1016/j.jgar.2020.06.026.

Pedersen T, Tellevik MG, Kommedal Ø, Lindemann PC, Moyo SJ, Janice J, Blomberg B, Samuelsen Ø, Langeland N. Horizontal Plasmid Transfer among Klebsiella pneumoniae Isolates Is the Key Factor for Dissemination of Extended-Spectrum β-Lactamases among Children in Tanzania. mSphere. 2020 Jul 15;5(4):e00428-20.​

Manyahi J, Moyo SJ, Tellevik MG, Ndugulile F, Urassa W, Blomberg B, Langeland N. Detection of CTX-M-15 beta-lactamases in Enterobacteriaceae causing hospital- and community-acquired urinary tract infections as early as 2004, in Dar es Salaam, Tanzania. BMC Infect Dis. 2017 Apr 17;17(1):282. doi:10.1186/s12879-017-2395-8.

Manyahi J, Tellevik MG, Ndugulile F, Moyo SJ, Langeland N, Blomberg B.
Molecular Characterization of Cotrimoxazole Resistance Genes and Their Associated Integrons in Clinical Isolates of Gram-Negative Bacteria from Tanzania. Microb Drug Resist. 2017 Jan;23(1):37-43. doi: 10.1089/mdr.2016.0074.

Tellevik MG, Blomberg B, Kommedal Ø, Maselle SY, Langeland N, Moyo SJ. High Prevalence of Faecal Carriage of ESBL-Producing Enterobacteriaceae among Children in Dar es Salaam, Tanzania. PLoS One. 2016 Dec 9;11(12):e0168024.

Onken A, Said AK, Jørstad M, Jenum PA, Blomberg B. Prevalence and Antimicrobial Resistance of Microbes Causing Bloodstream Infections in Unguja, Zanzibar. PLoS One. 2015 Dec 23;10(12):e0145632. doi: 10.1371/journal.pone.0145632.

Aamodt H, Mohn SC, Maselle S, Manji KP, Willems R, Jureen R, Langeland N, Blomberg B. Genetic relatedness and risk factor analysis of ampicillin-resistant and high-level gentamicin-resistant enterococci causing bloodstream infections in Tanzanian children. BMC Infect Dis. 2015 Feb 28;15:107. doi: 10.1186/s12879-015-0845-8.PMID: 25884316

Moyo S, Haldorsen B, Aboud S, Blomberg B, Maselle SY, Sundsfjord A, Langeland N, Samuelsen O. Identification of VIM-2-Producing Pseudomonas aeruginosa From Tanzania is Associated with Sequence Types 244 and 640 and the Location of blaVIM-2 in an TniC Integron. Antimicrob Agents Chemother. 2014 Oct 20. pii: AAC.01436-13.

Haug JB, Berild D, Blomberg B, Bruun JN, Flaatten HK, Leiva RA, Skrede S, Torfoss D, Undseth Ø. [Aminoglycosides in severe sepsis]. Tidsskr Nor Laegeforen 2013 Aug;133(15):1553-4. 

Moyo SJ, Aboud S, Blomberg B, Mkopi N, Kasubi M, Manji K, Lyamuya EF, Maselle SY, Langeland N. High Nasal Carriage of Methicillin-Resistant Staphylococcus aureus Among Healthy Tanzanian Under-5 Children. Microb Drug Resist. 2013 Sep 13.

Moyo SJ, Steinbakk M, Aboud S, Mkopi N, Kasubi M, Blomberg B, Manji K, Lyamuya EF, Maselle SY, Langeland N. Penicillin resistance and serotype distribution of Streptococcus pneumoniae in nasopharyngeal carrier children under 5 years of age in Dar es Salaam, Tanzania. J Med Microbiol 2012 Jul;61(Pt 7):952-9.

Moyo SJ, Njolstad G, Matee MI, Kitundu J, Myrmel H, Mylvaganam H, Maselle SY, Langeland N. Age specific aetiological agents of diarrhoea in hospitalized children aged less than five years in Dar es Salaam, Tanzania. BMC Pediatr 2011;11():19. 

Blomberg B. Antimicrobial resistance in developing countries. Tidsskr Nor Laegeforen. 2008 Nov 6;128(21):2462-6.  

Tellevik MG, Sollid JE, Blomberg B, Jureen R, Urassa WK, Langeland N. Extended-spectrum beta-lactamase-type SHV-12-producing Enterobacteriaceae causing septicemia in Tanzanian children: vectors for horizontal transfer of antimicrobial resistance. Diagn Microbiol Infect Dis. 2007 Nov;59(3):351-4. PMID: 17878065.

Blomberg B, Manji KP, Urassa WK, Tamim BS, Mwakagile DS, Jureen R, Msangi V, Tellevik MG, Holberg-Petersen M, Harthug S, Maselle SY, Langeland N. Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study. BMC Infect Dis. 2007 May 22;7:43. PMID: 17519011

Blomberg B, Jureen R, Manji KP, Tamim BS, Mwakagile DS, Urassa WK, Fataki M, Msangi V, Tellevik MG, Maselle SY, Langeland N. High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania. J Clin Microbiol. 2005 Feb;43(2):745-9.

Ndugulile F, Jureen R, Harthug S, Urassa W, Langeland N. Extended spectrum beta-lactamases among Gram-negative bacteria of nosocomial origin from an intensive care unit of a tertiary health facility in Tanzania. BMC Infect Dis. 2005 Oct 15;5:86.

Blomberg B, Olsen BE, Hinderaker SG, Langeland N, Gasheka P, Jureen R, Kvale G, Midtvedt T. Antimicrobial resistance in urinary bacterial isolates from pregnant women in rural Tanzania: implications for public health. Scand J Infect Dis. 2005;37(4):262-8.

Blomberg B, Mwakagile DS, Urassa WK, Maselle SY, Mashurano M, Digranes A, Harthug S, Langeland N. Surveillance of antimicrobial resistance at a tertiary hospital in Tanzania. BMC Public Health. 2004 Oct 11;4:45.

Vaagland H, Blomberg B, Kruger C, Naman N, Jureen R, Langeland N. Nosocomial outbreak of neonatal Salmonella enterica serotype Enteritidis meningitis in a rural hospital in northern Tanzania. BMC Infect Dis. 2004 Sep 14;4:35.