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Mohn Research Centre for

Regenerative Medicine

In Mohn Research Centre for Regenerative Medicine (MRCRM), we aim to develop new cell-based therapies to repair or replace - to regenerate - tissues and cells damaged by disease or injury. Our research focus spans from biomedical to clinical research and clinical trials within the field of regenerative medicine, and our long-term aim is to offer patients new state-of-the-art therapies.

The goal of the Mohn Research Centre for Regenerative Medicine (MRCRM) is to support and strengthen the research environment within regenerative medicine in Bergen, with a particular focus on translating basic research into clinical st​udies that, in turn, will benefit the patients.

​We envision the Centre as an umbrella for the scientific community within this research area, providing a common hub where new research collaborations and ideas can evolve and take the field to the next level. 

The Centre is a strategic initiative from Haukeland University Hospital at Helse Bergen Health Trust and the Faculty of Medicine at the University of Bergen, financed by Trond Mohn Research Foundation for five years (2021-2026). MRCRM builds on an active research environment and the newly established Ex-vivo facility at the Laboratory building at Haukeland. This labo​ratory is a high-grade cleanroom facility operating under Good Manufacturing Practice (GMP) and will manufacture the cells (referred to as Advanced Therapeutic Medicinal Products - ATMPs) for clinical trials affiliated with the Centre.

What are Advanced Therapeutic Medicinal Products?

An Advanced Therapeutic Medicinal Product (ATMP) is a medicine for human use that is based on genes, cells or tissue engineering.

The European Medicines Agency (EMA) classifies ATMP into three main types:

  • Gene therapy medicines: Genes that lead to therapeutic, prophylactic or diagnostic effects.
  • Somatic-cell therapy medicines: Manipulated cells or tissues used to cure, diagnose or prevent diseases.
  • Tissue-engineered medicines: Cells or tissues used to repair, regenerate or replace human tissue.

Combined ATMPs also include medical devices as part of the product. 

ATMPs are regulated under Regulation (EC) No 1394/2007 and Directive 2001/83/EC

 

The objectives of the MRCRM are to coordinate groundbreaking fundamental research, and give patients access to state-of-the-art therapies, initially in clinical trials but later as established advanced, personalized treatment, see below. We will achieve this by:

  • ​Being the hub for the scientific community

  • Supporting and promoting fundamental and translational stem cell research

  • Enabling clinical trials with advanced therapy medicinal products (ATMPs) based on tissues and cells, employing the new cleanroom laboratory at Haukeland University Hospital (i.e. the Ex-vivo facility)

  • Assisting in steering through the approval process by the Norwegian Medical Products Agency (NoMA)

  • Implementing novel therapies using ATMPs

 

In August 2021, the Helse Bergen Health Trust and the University of Bergen established the Mohn Research Centre for Regenerative Medicine. Four research projects, recruited through grants from the Trond Mohn Research Foundation, comprise the initial scientific foundation of the Centre. 

The Trond Mohn Research Foundation has generously supported the initiative with 30 MNOK, and the host institutions have contributed with in total 60 MNOK. The Helse Bergen Health Trust has also invested a considerable amount in the new “Ex Vivo” cell production facility, which will be operable at Haukeland University Hospital by the end of 2022. 

The administrative unit of the Centre is located at the Department of Immunology and Transfusion Medicine in the Laboratory Building at Haukeland University Hospital. Still, our research is spread to dedicated laboratories and buildings around Bergen. Thus, so far this is a centre “without walls”. ​

The MRCRM Team

The appointed centre leader is Professor and MD Einar K. Kristoffersen, Head of the Department of Immunology and Transfusion Medicine at Haukeland University Hospital. He chairs the MRCRM Management group​, which meets monthly to discuss strategic and practical issues. 
 
The MRCRM Steering Group is chaired by the Helse Bergen deputy CEO Clara Gjesdal, and consists of representatives from the Helse Bergen Health Trust, the University of Bergen and the Trond Mohn Research Foundation. 
 
An international Scientific Advisory Board ​(SAB) has been established and consists of representatives with high compentency on cell therapy and research centre development. The role of the SAB ​is to support and evaluate the Centre.
 

 

If you would like to join the Centre or be informed about MRCRM-related activities and upcoming events, send us an e-mail or see contact information below​. ​​​​

Logo MRCRM - Mohn Research Centre for Regenerative Medicine

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    Upcoming events

    • MRCRM "How to" series - 2024
      This semester, we are introducing a new seminar series concept called “How to” - a format that encourages speakers to share their knowledge and expertise so that others can learn from it.
      MRCRM "How to" series - 2024
      12.
      november
      2024
    • UniStem Day 2025
      High-schools in and close to Bergen will be invited during the fall semester, and are also welcome to get in touch to reserve a spot. 
      UniStem Day 2025
      14.
      mars
      2025
    • MRCRM 3rd International Meeting on Regenerative Medicine 2025
      The Mohn Research Centre for Regenerative Medicine (MRCRM) invites you to join our third international meeting in Bergen, May 12 - 13 (tentative), 2025.
      MRCRM 3rd International Meeting on Regenerative Medicine 2025
      12.
      mai
      2025
      2 days

    News

      High-school students first encounter with stem cell research

      On Friday, March 22, 2024, UniStem Day was celebrated worldwide, with 97 participating research centres and universities. Norway joined the initiative for the very first time, and gathered 80 high school students from Bergen to explore the possibilities within stem cell research - a field that has the potential to revolutionize future medicine.

      UniStem Day 2024 in Bergen
      A group of people sitting in a room

      What Happens in a Bone Tissue Engineering Lab?

      A man with his hand on his face

      Einar Klæboe Kristoffersen

      Centre leader, Mohn Research Centre for Regenerative Medicine

      einar.kleboe.kristoffersen@helse-bergen.no +47 55 97 46 83

      Head of Department, Professor II
      Department of Immunology and Transfusion
      Haukeland University Hospital

      Elise Aasebø

      Elise Aasebø

      Coordinator, Mohn Research Centre for Regenerative Medicine

      elise.aasebo@helse-bergen.no +47 55 97 30 45

      PhD

      Department of Immunology and Transfusion
      Haukeland University Hospital

      Text
      The Mohn Research Centre for Regenerative Medicine is supported by the Trond Mohn Research Foundation, University of Bergen, and Haukeland University Hospital.​​​​
      Last updated 10/7/2024