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Research

The objectives of the MRCRM are to coordinate groundbreaking fundamental research, and give patients access to state-of-the-art therapies, initially in clinical trials but later as established advanced, personalized treatment.

Image of scientist with protective mask, hair net and glasses looking at a futuristic screen

Photo: Colourbox.com (#25456261)

The Mohn Research Centre for Regenerative Medicine has four core projects, recruited through grants from the Trond Mohn Research Foundation in 2021. 

Several other projects and centres are closely affilitated to the MRCRM and the Ex-vivo facility, where cell products for clinical trials will be be manufacured. 

Core projects funded by the Trond Mohn Research Foundation

Affiliated activities

Projects

  • Cellu4Heal - Research Council of Norway (M-ERA.NET). Led by Prof. Kamal Mustafa and Ass. prof Stian K. Almeland
  • MaxiBone - a European project aiming to create personalized maxillary bone regeneration by using culture expanded autologous bone marrow stem cells and biomaterials. Coordinated by prof. Pierre Layrolle at Inserm UMR 1238, Phy-Os, University of Nantes and prof. Kamal Mustafa. The clinical trial  i sponsored and led by prof. Kamal Mustafa and Cecilie Gjerde at the Department of Clinical Odontology (IKO), University of Bergen (UiB).
  • Immune-driven tissue regeneration/StemReg, a TMF funded project led by researcher Salwa Suliman (UiB).
  • The SMART-MS clinical trial, led by Prof. Lars Bø (UiB, Helse Bergen) and Christopher Kvistad (MD PhD, Helse Bergen) is a phase I/II interventional clinical trial with MSC transplantation in 18 patients with Multiple Sclerosis. Recruitment and treatment are completed, and the patients are followed up for 18 months. ClinicalTrials.gov ID: NCT04749667.
  • «Clinical evaluation of CD37 CAR T for acute myeloid leukaemia”, a KLINBEFORSK funded project led by Prof. Bjørn Tore Gjertsen, Helse Bergen/UiB. 
  • BergenLys is an innovation project at Haukeland University Hospital. It focuses on utilizing expired blood platelet products to generate platelet lysate, termed “BergenLys”, which contains essential growth factors for cell manufacturing in GMP facilities.
  • StemBoneReg: Reconstruction of mandibular bone using stem cells and biomedical engineering approaches, a TMF funded project led by Prof. Kamal Mustafa (UiB).
  • Alden Cancer Therapy II, is an innovative cryo-immunotherapy (“Cryo-IT”) project based on dendritic cells, led by Prof. Karl-Henning Kalland (UiB). The cells for the phase II clinical trial will be produced in the Ex-vivo facility in Bergen.
  • BoneFix: A Paradigm Shift in Fracture Fixations via On-Site Fabrication of Bone Restoration Patches. Led by prof. Kamal Mustafa, Department of Clinical Odontology (IKO), UiB (Bergen Tissue Engineering Group).  H2020 project no. 952150,– EU Commission  
  • 3DPRENT: 3D Printed Engineered Nano-Composite Templates for Bone Regeneration (Bergen Tissue Engineering Group)
  • 3D-printed scaffolds for Bone Regeneration - The major goal of this project is to develop 3D printed scaffolds with novel designs for vascularized long bone regeneration. The project is led by Prof. Kamal Mustafa at Bergen Tissue Engineering Group, and is funded by the Research Council of Norway (RCN, NANO2021), no. 302043 
  • OralMaxiBone: Stem Cell Therapy for Bone Regeneration in Maxillofacial and Orthopaedic Surgery. Funded by the Research Council of Norway. (Bergen Tissue Engineering Group).
  • StemCellReg, BFS2018TMT10,– Trond Mohn Research Foundation, led by Prof. Kamal Mustafa
  • Let`s make bone, Award for Nordic Research,– funded by Olav Thon Foundation, led by Prof. Kamal Mustafa
  • VIS and UiB, FORNY 2020,– Research Council of Norway, RCN. Led by Prof. Kamal Mustafa
  • NORCEL project (228147/O70), - Research Council of Norway. Led by Prof. Kamal Mustafa
  • Vascubone project (FP7-HEALTH-2009 EU project. Led by Prof. Kamal Mustafa
  • REBORNE project (FP7-HEALTH-2009 EU project), WP leader, Sponsor of multicenter trial. Led by Prof. Kamal Mustafa

Centres/hubs

 

If you have a project or research group that should be affiliated to the MRCRM, please get in touch!

Last updated 8/22/2024