Sykdomsmodulerende behandling av multippel sklerose - en review av godkjente medikamenter

Denne studien er basert på litteratursøk av publiserte randomiserte kontrollerte fase III forsøk av sykdomsmodulerende medikamenter godkjent for RRMS, indeksert i PubMed til 21 mai 2015. Studien er utført av forskere tilknyttet kompetansetjenesten, og er publisert i det internasjonale tidsskriftet Eur J Neurol.

Publisert 17.01.2017
Sist oppdatert 19.09.2017


There is still no curative treatment for multiple sclerosis (MS), but during the last 20 years eight different disease-modifying compounds have been approved for relapsing-remitting MS (RRMS).


A literature search was conducted on published randomized controlled phase III trials indexed in PubMed on the approved medications until 21 May 2015.


In this review the mode of action, documented treatment effects and side effects of the approved MS therapies are briefly discussed.


Based on current knowledge of risk-benefit of the approved MS medications, including factors influencing adherence, it is suggested that oral treatment with dimethyl fumarate or teriflunomide should be preferred as a starting therapy amongst the first-line preparations for de novo RRMS. In the case of breakthrough disease on first-line therapy, or rapidly evolving severe RRMS, second-line therapy with natalizumab, fingolimod or alemtuzumab should be chosen based on careful risk-benefit stratification.


Torkildsen Ø, Myhr KM, Bø L. Disease-modifying treatments for multiple sclerosis - a review of approved medications. Eur J Neurol. 2016 Jan;23 Suppl 1:18-27