En valideringsstudie av polygrafi med øsofagial probe sammenlignet med polysomnografi ved obstruktiv søvnapné
Forskere fra Akershus universitetssykehus og Universitetet i Oslo har i denne studien validert de automatisk skårede resultatene av et øsofagialprobe-basert polygrafsystem (PG) mot manuelt skåret polysomnografi PSG ved å sammenligne apné-hypopné-indeksen, oksygenmetningsindeksen og indeks for forstyrrelse av respirasjon. 83 pasienter henvist for oppfølging av obstruktiv søvnapné (OSA) ble testet samtidig med øsofagial-PG og PSG i en natt, og PSG-resultatene ble scoret uavhengig. Resultatet av studien viste at øsofagial-PG var sammenlignbart med PSG hos pasienter med moderat OSA (AHI=15), men overvurderte mild OSA (AHI≤15) og undervurderte alvorlig OSA (AHI≥15) sammenlignet med PSG.
Publisert 03.06.2022
Thorarinn Arnar Olafsson, Eivind Andreas Steinsvik, Gregor Bachmann-Harildstad, Harald Hrubos-Strøm
Studien er publisert i Sleep and Breathing
Study objectives: The aim of this study was to validate the automatically scored results of an esophageal probe-based polygraph system (ApneaGraph® Spiro) against manually scored polysomnography (Nox A1, PSG) results. We compared the apnea-hypopnea index, oxygen saturation index, and respiratory disturbance index of the devices.
Methods: Consenting patients, referred for obstructive sleep apnea workup, were tested simultaneously with the ApneaGraph® Spiro and Nox A1® polysomnograph. Each participant made one set of simultaneous registrations for one night. PSG results were scored independently. Apnea-hypopnea index, oxygen desaturation index, and respiratory disturbance index were compared using Pearson's correlation and scatter plots. Sensitivity, specificity, and positive likelihood ratio of all indices at 5, 15, and 30 were calculated.
Results: A total of 83 participants had successful registrations. The apnea-hypopnea index showed sensitivity of 0.83, specificity of 0.95, and a positive likelihood ratio of 5.11 at an index cutoff of 15. At a cutoff of 30, the positive likelihood ratio rose to 31.43. The respiratory disturbance index showed high sensitivity (> 0.9) at all cutoffs, but specificity was below 0.5 at all cutoffs. Scatterplots revealed overestimation in mild OSA and underestimation in severe OSA for all three indices.
Conclusions: The ApneaGraph® Spiro performed acceptably when OSA was defined by an AHI of 15. The equipment overestimated mild OSA and underestimated severe OSA, compared to the PSG.