Chronic kidney disease

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​​​Chronic kidney disease (CKD) has a major and increasing impact on morbidity and mortality worldwide. In fact, CKD is the 10th leading cause of death globally and is expected to become the fifth leading cause of death by 2040 above all cancer types. The economic burden of chronic kidney disease and renal replacement therapy is enormous: Aggregated health care costs for CKD in Europe are in the range or exceed the costs for diabetes and cancer.

A kidney biopsy is often the only option to correctly diagnose the renal disease and to gain information about prognosis and possible treatment.​ Our kidney disease projects focus on how computational pathology can assist the nephropathologist to classify kidney lesions and to quantify prognostic and predictive biomarkers.​​

Work package 2: Fibrosis in kidney biopsies

Interstitial fibrosis is one of the crucial prognostic markers in non-neoplastic kidney biopsies. Currently fibrosis is estimated by eyeballing, which allows only a very rough estimate of the degree of fibrosis.
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Kidney fibrosis

Work package 6: Automatic classification of glomerular lesions

Glomeruli are capillary tufts filtering waste products from the blood and forming urine together with the tubular system. Glomeruli can be affected by a multitude of diseases and show very diverse lesions.
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Glomerular lesions
Sist oppdatert 16.05.2022