Forskning og utvikling

Vi har flere aktive forsknings- og innovasjonsmiljøer innen våre fagområder og bistår både offentlige og private aktører med hendelsesutredninger og konsulenttjenester

Foto: Kon Tiki

Senteret driver forskning og rådgivning innen maritim medisin og dykkemedisin

Forskningen i senteret er viktig for å kunne gi gode og oppdaterte helsetjenester til sjøfolk og yrkesdykkere, bidra til å utvikle maritim medisin og dykkemedisin, og for å gi gode rådgivningstjenester.

Innenfor maritim medisin har vi forskning på

  • Seleksjonsmedisin
  • Registerstudier

Senteret arbeider med å få etablert et Norsk Maritim Helseregister. Hensikten er å samle helsedata om sjømenn for å gi et faglig godt grunnlag for seleksjon, HMS-tiltak, forskning og utvikling.

Yrkesdykking og forskning innenfor dykkemedisin

Den dykkemedisinske forskningen er fokusert mot yrkesdykking, både utaskjærs og innaskjærs

  • Epidemiologiske studier av yrkesdykkere
  • Fysiologiske, cellulære og biokjemiske responser på dykking

Sentret har et hyperbart cellelaboratorium for eksperimentelle studier. Her kan vi studere effekter av trykk, oksygen, ulike inerte gasser og dekompresjon på cellulære og biokjemiske funksjoner. Vi forsker i hovedsak på modellsystemer som er relevant for å forstå helseeffekter på nerve- og hjerte-kar systemet.


Tidsskriftet International Maritime Health

Forside International Maritime Health
Senteret er med på å utgi det eneste engelskspråklige fagfellevurderte og indekserte tidsskrift i maritim medisin. Tidsskriftet International Maritime Health utgis i Gdynia, Polen. Her kan du lese siste utgave av tidsskriftet. 

 Yrkesmedisinsk Avdeling er med i stiftelsen International Maritime Health Foundation som utgir tidsskriftet.

 

 

Vitenskapelige arbeider fra senteret

Vitenskapelige publikasjoner (siste 10 år)

Szigetvari PD, Patil S, Birkeland E, Kleppe R, Haavik J. The effects of phenylalanine and tyrosine levels on dopamine production in rat PC12 cells. Implications for treatment of phenylketonuria, tyrosinemia type 1 and comorbid neurodevelopmental disorders. Neurochem Int. 2023: 171:105629. doi: 10.1016/j.neuint.2023.105629

Roberts SE, John A, Carter T, G Williams J. Suicide rates in the UK Armed Forces, compared with the general workforce and merchant shipping during peacetime years since 1900. BMJ Mil Health. 2023 Apr 7:e002309. doi: 10.1136/military-2022-002309

Nikolić N, Haga JM, Tülsner J, Årland PO, Horneland AM, Kavanagh B, Seidenstucker K, Briggs S, Lund-Kordahl I, Pernilla CS. Medical training of seafarers: International Maritime Health Foundation (IMHF) Expert Panel Consensus Statement. Int Marit Health. 2023;74(1):15-23. doi: 10.5603/IMH.2023.0002

Sundal E, Lygre SHL, Irgens Å, Troland K, Grønning M. Long-term neurological sequelae after decompression sickness in retired professional divers. J Neurol Sci. 2022 Mar 15;434:120181. doi: 10.1016/j.jns.2022.120181.

Bueno-Carrasco MT, Cuéllar J, Flydal MI, Santiago C, Kråkenes TA, Kleppe R, López-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacón P, Martinez A, Valpuesta JM. Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun. 2022 Jan 10;13(1):74. doi: 10.1038/s41467-021-27657-y.

Cannon Homaei S, Barone H, Kleppe R, Betari N, Reif A, Haavik J. ADHD symptoms in neurometabolic diseases: Underlying mechanisms and clinical implications. Neurosci Biobehav Rev. 2022 Jan;132:838-856. doi: 10.1016/j.neubiorev.2021.11.012.

Kleppe R, Waheed Q, Ruoff P. DOPA Homeostasis by Dopamine: A Control-Theoretic View. Int J Mol Sci. 2021 Nov 28;22(23):12862. doi: 10.3390/ijms222312862.

Djurhuus R. Fumigation on bulk cargo ships: a chemical threat to seafarers. Int Marit Health. 2021;72(3):206-216. doi: 10.5603/IMH.2021.0039

Nygaard G, Szigetvari PD, Grindheim AK, Ruoff P, Martinez A, Haavik J, Kleppe R, Flydal MI. Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia-A Focus on Tyrosine Hydroxylase Deficiency. J Pers Med. 2021 Nov 12;11(11):1186. doi: 10.3390/jpm11111186

Roberts SE, Carter T, Smith HD, John A, Williams JG. Forgotten fatalities: British military, mining and maritime accidents since 1900. Occup Med (Lond). 2021 Oct 1;71(6-7):277-283. doi: 10.1093/occmed/kqab108

Waløen K, Jung-Kc K, Vecchia ED, Pandey S, Gasparik N, Døskeland A, Patil S, Kleppe R, Hritz J, Norton WHJ, Martinez A, Haavik J. Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins. Mol Pharmacol. 2021 Aug;100(2):155-169. doi: 10.1124/molpharm.120.000184.

Koefoed VF, Miles T, Cason JB, Troche R. Colour vision classification - comparing CAD and CIE 143:2001 International recommendations for colour vision requirements in transport. Acta Ophthalmol. 2020 Nov;98(7):726-735. doi: 10.1111/aos.14450

Hesthammer R, Dahle S, Storesund JP, Eide T, Djurhuus R, Svardal AM, Thorsen E. Nitric oxide in exhaled gas and tetrahydrobiopterin in plasma after exposure to hyperoxia. Undersea Hyperb Med. 2020 Second Quarter;47(2):197-202. doi: 10.22462/04.06.2020.4

Stannard S. COVID-19 in the maritime setting: the challenges, regulations and the international response. Int Marit Health. 2020;71(2):85-90. doi: 10.5603/IMH.2020.0016

Carter T, John A, Williams JG, Roberts SE. Suicide, fatal injuries and drowning among the crews of United Kingdom and Bermuda registered cruise and passenger ships from 1976 to 2018. Int Marit Health. 2020;71(1):12-19. doi: 10.5603/IMH.2020.0006

Dahl E. Coronavirus (Covid-19) outbreak on the cruise ship Diamond Princess. Int Marit Health. 2020;71(1):5-8. doi: 10.5603/MH.2020.0003

Dahl E. Medical ultrasound on cruise ship. Int Marit Health. 2020;71(1):10-11. doi: 10.5603/IMH.2020.0005

Dahl E. Large-scale helicopter rescue of cruise passengers and freighter crew off the coast of Norway in stormy weather. Int Marit Health. 2019;70(2):79-81. doi: 10.5603/IMH.2019.0012

Flatmo F, Grønning M, Irgens Å. Musculoskeletal complaints among professional divers. Int Marit Health. 2019;70(2):107-112. doi: 10.5603/IMH.2019.0017

Hesthammer R, Eide T, Thorsen E, Svardal AM, Djurhuus R. Hyperoxia and lack of ascorbic acid deplete tetrahydrobiopterin without affecting NO generation in endothelial cells. Undersea Hyperb Med. 2019 Jun-Jul-Aug - Third Quarter;46(4):509-519

Hesthammer R, Eide T, Thorsen E, Svardal AM, Djurhuus R. Decrease of tetrahydrobiopterin and NO generation in endothelial cells exposed to simulated diving. Undersea Hyperb Med. 2019 Mar-Apr-May;46(2):159-169

Carter T, Williams JG, Roberts SE. Crew and passenger deaths from vessel accidents in United Kingdom passenger ships since 1900. Int Marit Health. 2019;70(1):1-10. doi: 10.5603/IMH.2019.0001

Nikolić N, Nilson R, Briggs S, Ulven AJ, Tveten A, Forbes S, Vaz Pardal C, Viruly L, Verbist R. A Medical Support in Offshore Racing - Workshop on Medical Support for Offshore Yacht Races, Telemedical Advice Service (TMAS), 1-2 December 2018, London, United Kingdom. Int Marit Health. 2019;70(1):27-41. doi: 10.5603/IMH.2019.0005

Dahl E. Vessel sanitation inspection scores and acute gastroenteritis outbreaks on cruise ships. Int Marit Health. 2018;69(4):223-224. doi: 10.5603/IMH.2018.0036

Horneland AM, Jeżewska M, Jaremin B, Kotłowski A, Sommerfelt-Pettersen J, Grønning M, Korzeniewski K, Grubman-Nowak M. Establishment of the International Maritime Health Foundation: the next step in scientific publishing in maritime health. Int Marit Health. 2018;69(3):153-156. doi: 10.5603/IMH.2018.0024

Bjørkum AA, Oveland E, Stuhr L, Havnes MB, Berven F, Grønning M, Hope A. Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats. PLoS One. 2017 Oct 4;12(10):e0185765. doi: 10.1371/journal.pone.0185765

Åsmul K, Irgens Å, Grønning M, Møllerløkken A. Diving and long-term cardiovascular health. Occup Med (Lond). 2017 Jul 1;67(5):371-376. doi: 10.1093/occmed/kqx049

Irgens Å, Troland K, Grønning M. Female professional divers. Similarities and differences between male and female professional divers. Int Marit Health. 2017;68(1):60-67. doi: 10.5603/IMH.2017.0010

Horneland AM, Stannard SL. Decision aid for the use of additional tests during the pre-employment medical examination (PEME) of seafarers. Int Marit Health. 2017;68(2):90-98. doi: 10.5603/IMH.2017.0017

Holt TE, Tveten A, Dahl E. Medical emergencies on large passenger ships without doctors: the Oslo-Kiel-Oslo ferry experience. Int Marit Health. 2017;68(3):153-158. doi: 10.5603/IMH.2017.0027

Irgens Å, Troland K, Djurhuus R, Grønning M. Diving exposure and health effects in divers working in different areas of professional diving. Int Marit Health. 2016;67(4):235-242. doi: 10.5603/IMH.2016.0042

Æsøy MS, Solvang SH, Grønning M, Rekand T. Epidemiology of persistent iatrogenic spinal cord injuries in Western Norway. Brain Behav. 2016 Jul 7;6(10):e00522. doi: 10.1002/brb3.522

Irgens Å, Grønning M, Irgens LM. Pregnancy outcome in partners of male professional divers in Norway. Occup Med (Lond). 2016 Nov 1;66(8):600-606. doi: 10.1093/occmed/kqw087

Irgens Å, Djurhuus R, Grønning M. Mortality among retired offshore divers in Norway. Int Marit Health. 2015;66(2):93-6. doi: 10.5603/IMH.2015.0022

Hope A, Stuhr LB, Pavlin T, Bjørkum AA, Grønning M. MRI of the central nervous system in rats following heliox saturation decompression. Undersea Hyperb Med. 2015 Jan-Feb;42(1):57-64

Baur X, Budnik LT, Zhao Z, Bratveit M, Djurhuus R, Verschoor L, Rubino FM, Colosio C, Jepsen JR. Health risks in international container and bulk cargo transport due to volatile toxic compounds. J Occup Med Toxicol. 2015 May 20;10:19. doi: 10.1186/s12995-015-0059-4

 

PhD avhandlinger

Ronja Hesthammer. 2019. Tetrahydrobiopterin and nitric oxide synthesis after exposure to hyperoxia and simulated diving. An experimental study in human endothelial cells and healthy humans. PhD.

Vilhelm F Koefoed. 2018. A proper lookout. «En skikket utkikk». PhD.

 

Master- og hovedoppgaver

Sofie Breisnes Wormdahl, Effect of simulated saturation diving on dopamine synthesis regulation. Masteroppgave i molekylærbiologi, 2023. Hovedveileder: Rune Kleppe

Marte Elise Eide og Marie Ryen Brabec, Dopamine under pressure – A literature study on the effects of diving-conditions on dopaminergic neurotransmission and possible implications for improved safety of occupational diving. Hovedoppgave for medisinere, 2022. Hovedveileder: Rune Kleppe

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Våre forskningsprosjekter

    Sist oppdatert 30.01.2024