Selvrapporterte insomnisymptomer, søvnlengde, døgnrytmepreferanse og risiko for akutt hjerteinfarkt.
Insomni og kort/lang søvnlengde øker risikoen for akutt hjerteinfarkt, men interaksjon med hverandre eller med døgnrytmepreferanse er ikke godt undersøkt. Forskere fra NTNU, University of Bristol, St. Olavs hospital og Levanger sykehus har i denne studien undersøkt mulige felles assosiasjoner til to av disse søvnkarakteristika på risiko for akutt hjerteinfarkt. Mere enn 330.000 pasienter uten tidligere akutt hjerteinfarkt fra henholdsvis UK Biobank og HUNT2 ble inkludert i studien. Insomnisymptomer med lang søvnlengde kan bidra til mer enn bare en additiv effekt av disse søvnkarakteristika på risikoen for akutt hjerteinfarkt.
Nikhil Arora, Rebecca Claire Richmond, Ben Michael Brumpton, Bjørn Olav Åsvold, Håvard Dalen, Eivind Schjelderup Skarpsno, Linn Beate Strand
Studien er publisert i European Journal of Epidemiology
Insomnia and short/long sleep duration increase the risk of AMI, but their interaction with each other or with chronotype is not well known. We investigated the prospective joint associations of any two of these sleep traits on risk of AMI. We included 302 456 and 31 091 participants without past AMI episodes from UK Biobank (UKBB; 2006-10) and the Trøndelag Health Study (HUNT2; 1995-97), respectively. A total of 6 833 and 2 540 incident AMIs were identified during an average 11.7 and 21.0 years follow-up, in UKBB and HUNT2, respectively. Compared to those who reported normal sleep duration (7-8 h) without insomnia symptoms, the Cox proportional hazard ratios (HRs) for incident AMI in UKBB among participants who reported normal, short and long sleep duration with insomnia symptoms were 1.07 (95% CI 0.99, 1.15), 1.16 (95% CI 1.07, 1.25) and 1.40 (95% CI 1.21, 1.63), respectively. The corresponding HRs in HUNT2 were 1.09 (95% CI 0.95, 1.25), 1.17 (95% CI 0.87, 1.58) and 1.02 (95% CI 0.85, 1.23). The HRs for incident AMI in UKBB among evening chronotypes were 1.19 (95% CI 1.10, 1.29) for those who had insomnia symptoms, 1.18 (95% CI 1.08, 1.29) for those with short sleep duration, and 1.21 (95% CI 1.07, 1.37) for those with long sleep duration, compared to morning chronotypes without another sleep symptom. The relative excess risk for incident AMI in UKBB due to interaction between insomnia symptoms and long sleep duration was 0.25 (95% CI 0.01, 0.48). Insomnia symptoms with long sleep duration may contribute more than just an additive effect of these sleep traits on the risk of AMI.