Sammenheng mellom fysisk kondisjon og kjøp av reseptbelagt sovemedisin.
Forskere fra NTNU, University of South Carolina-USA, St Olavs hospital, Universidad Pública de Navarra-Pamplona, Nord universitet, Nasjonal kompetansetjeneste for søvnsykdommer og Universitetet i Bergen har i denne studien undersøkt sammenheng mellom personer med god fysisk form og bruk av reseptbelagt sovemedisin hos 5791 deltagere i HUNT-3 undesøkelsen som fikk sin første resept på sovemedisin i undersøkelsesperioden. Resultatene viste at det var færre med god fysisk kondisjon som fikk utskrevet sin første resept på sovemedisin enn de med dårlige kondisjon, noe som kan tyde på at god fysisk form er positivt for god søvnhelse.
Publisert 10.11.2022
Linda Ernstsen, Ekaterina Zotcheva, Xuemei Sui, Morten Engstrøm, Nicolás Martínez-Velilla, Ottar Bjerkeset, Bjørn Bjorvatn, Audun Havnen
Studien er publisert i Mayo Clinic Proceedings
Objective: To assess whether cardiorespiratory fitness (CRF) is associated with first purchase of a prescribed hypnotic drug in the adult population.
Methods: A total of 34,357 adult participants (53.9% women) with a mean age of 51.5 years (SD 15.6 years) from the third Trøndelag Health Study (HUNT) of 2006 to 2008 were observed until January 1, 2018. Cardiorespiratory fitness was estimated from a validated nonexercise algorithm. Data on first hypnotics prescription were obtained through linkage to the National Norwegian Prescription Database. Cox regression with 95% CIs was used to estimate hazard ratios (HRs).
Results: After 304,899 person-years of follow-up, 5791 participants had their first registered purchase of prescribed hypnotics, corresponding to an incidence rate of 1.90 per 100 person-years. Each 1-metabolic equivalent of task increase in CRF was significantly associated with 5% (HR, 0.95; 95% CI, 0.91 to 0.99; P=.02) and 4% (HR, 0.96; 95% CI, 0.92 to 1.00; P=.046) risk reduction for incident use of hypnotics in men and women, respectively. When CRF was categorized into tertiles with lowest CRF as the reference group, reduced risk was 13% (HR, 0.87; 95% CI, 0.79 to 0.96; P=.006) and 15% (HR, 0.85; 95% CI, 0.77 to 0.95; P=.003) for men in the intermediate and highest CRF category, respectively. In women with highest CRF, the reduced risk was 5% (HR, 0.95; 95% CI, 0.87 to 1.03; P=.22).
Conclusion: Cardiorespiratory fitness in adulthood is associated with incident purchase of prescription medication commonly used for sleep problems. These findings suggest that fitness should be considered a target for preventing sleep problems in adults.